30% of Caucasians, 50% Asians and nearly 100% of all dark skinned people are born insulin resistant, which can lead to metabolic syndrome. In our bodies, the blood carries all the nutrients and energy to the cells. On each cell there is a receptor that opens the door to the cell so these nutrients can pass through.
The receptor is activated by insulin, a hormone secreted from the pancreas. If you are insulin resistant, the door to each cell is jammed, so the body has to produce more insulin to cope. If you are born insulin resistant, your body has had to make more insulin your whole life. As you get older the pancreas tends to give up and you end up with increased blood sugar levels (diabetes) and other factors associated with Insulin Resistence.
Factors associated with Insulin Resistence include:
- Increased Blood sugar > 7.5mmol/l
- Increased Blood pressure >135/85
- Dislypidaemia – Increased total cholesterol, LDL,triglycerides and decreased HDL
- Abdominal obesity M<95cm W<80cm
- CVD-progressive build up of fat in the wall of arteries
This group of symptoms is known as Metabolic Syndrome and is an increasing problem throughout the world.
Bergamet is the only supplement, both nutraceutical and pharmaceutical that addresses all the symptoms of metabolic syndrome.
Bergamot is positioned to become a first-line therapy for individuals with metabolic syndrome. In addition to its positive effects on cardiovascular risk factors, this extract also activates AMPK. AMPK is a central regulator of energy and is thus involved in glucose and fatty acid metabolism. “Turning on” AMPK improves insulin sensitivity, promotes glucose uptake in cells, and suppresses the synthesis of glucose in the liver, thus lowering blood sugar.
It also stimulates the burning of free fatty acids and facilitates weight control.
IDF Worldwide Definition of the Metabolic Syndrome
The metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure.
- A quarter of the world’s adults have metabolic syndrome and the condition increases in frequency with age.
- People with metabolic syndrome are twice as likely to die from, and three times as likely to have a heart attack or stroke compared with people without the syndrome
- It is the exact nature of the cluster which appears to bring additional risk over and above that which would be expected from each of the components (high triglycerides when measuring cholesterol, for example).
- People with metabolic syndrome have a five-fold greater risk of developing type 2 diabetes
- Up to 80% of the 200 million people with diabetes globally will die of cardiovascular disease
- This puts metabolic syndrome and diabetes way ahead of HIV/AIDS in morbidity and mortality terms yet the problem is not as well recognised
For a person to be defined as having the metabolic syndrome, the new definition requires they have central obesity, plus two of the following four additional factors: raised triglycerides (TG), reduced HDL-cholesterol, raised blood pressure or raised fasting plasma glucose level. Gender and, for the first time, ethnicity specific cut-off points for central obesity as measured by waist circumference are included.
According to the International Diabetes Federation definition, for a person to be defined as having the metabolic syndrome, they must have:
- Central obesity (defined as waist circumference ≥ 94 cm for Europid men and ≥ 80 cm for Europid women, with ethnicity specific values for other groups*)
plus any two of the following four factors:
- raised serum triglyceride level (≥ 1.7 mmol/L)
- reduced serum HDL-cholesterol level (< 1.03 mmol/L in males and < 1.29 mmol/L in females),
- raised blood pressure (systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg), or treatment of previously diagnosed hypertension
- impaired fasting glycaemia (fasting plasma glucose [FPG] ≥ 5.6 mmol/L), or previously diagnosed type 2 diabetes